| Varieties: | Parasite Disease Prevention Medicine |
|---|---|
| Component: | Botany |
| Type: | The First Class |
| Pharmacodynamic Influential Factors: | Repeated Medication |
| Storage Method: | Prevent High or LowTemperature |
| Veterinary Reg. No.: | Shouyaozhunzihao |
| Samples: |
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| Customization: |
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HERB-COC
(New Type Herbal Extraction for Coccidiosis )
Composition: per ml contains
Purslane Extract 20 mg
Areca-nut Extract 10 mg
Solvents upto 1 ml
Indications:
1. Repair Intestinal Mucosa and restore intestinal function rapidly.
2. Used for prevent and treatment coccidiosis of all stages like schizogony and gametogony stages stages of Eimeria spp. in chicken and turkey.
3. Make up the defect of traditional coccidium medicine drug resistance problem(such as Toltrazuril , Diclazuril,Sulfonamides), this product no drug resistance for long period medication.
4. Pure herbal extract product can be used for all stage of poultry. Green and healthy, no drug residue.
Dosage:
For oral administration via drinking water:
Poultry: 1ml per 1L water, for 3-5 consecutive days.
Double dosage during serious condition.
Notice: This product has better treatment result when use with enteritis medicines.
Withdrawal times: None
Warning: Keep in cool dark place below 30 ºC. Keep out of reach of children.
Packing: Bottle of 250ml 500 ml.
Validity: 2 years
How to prevent poultry coccidiosis?
Poultry coccidiosis is a parasitic disease caused by poultry coccidiosis. It can cause a high mortality rate in an acute outbreak, and it is resistant to the growth of diseased poultry. The weight gain is slow, which is a serious hazard to the poultry industry.
[Popular characteristics]
Poultry of all ages are susceptible, and the chicks of 2 to 4 weeks old are more frequent. Poultry raised on the ground are more susceptible to disease than those raised on the net, especially when the chicks are raised from the net to the ground. The season of poultry coccidiosis is closely related to temperature and rainfall. Usually the temperature is between 22~30C, and the disease is prone to spread in the rainy season. In general, coccidiosis away from home usually occurs in April to September. Diseased and infected poultry, as well as fecal-contaminated feed, drinking water, litter, etc., can transmit coccidiosis, which is mainly infected through the cleansing tract. When the poultry swallows the oocysts of coccidia, it can be infected.
[Clinical symptoms]
Sick poultry is depressed, lying prone, and anorexia. The characteristic is acute hemorrhagic diarrhea. Exhaust dark red or brown feces. The mortality rate of severe coccidiosis can be as high as 70%, the incidence can be as high as 90%, and the tolerant chicks grow slowly.
[Pathological changes]
In the acute type, severe hemorrhagic catarrhal enteritis and swelling of the small intestine can be seen. Bleeding, bleeding spots and bleeding spots can be seen in the duodenum. The intestinal contents are light red or bright red mucus or jelly-like messy fluid. Bleeding is particularly obvious before and after the yolk pedicle.
[Prevention and Control Measures]
(1) The focus of prevention of poultry coccidiosis should be to clean the poultry house, keep the poultry house dry, and remove the feces every day, because after the coccidian oocysts are excreted with the feces, under suitable conditions, it takes about It takes 1-3 days to develop infectious spore oocysts, and the chance of poultry infection with coccidiosis should be minimized. (2) Clean the poultry house regularly. During the coccidia epidemic season, ground breeding can be converted to online breeding, or preventive drug administration. (3) Commonly used anticoccidial drugs in clinical practice are: sulfamethazine, add 0.5% to the feed, feed continuously for 3 days, stop for 2 days, and then feed for 2 days: sulfamethoxazine, at 0.05%~ 0.2% mixed into the feed, used for 3~5 days: more grams of balls, mixed in the feed at 0.05%, continuously fed for 10 days: Aminophenylguanidine, mixed into the feed according to (30~33)X10″, used continuously for 4~5 days
How to prevent and control poultry virus diseases?
Viral diseases of poultry: In recent years, as the scale of poultry farming continues to increase, viral diseases have become the number one killer that harms poultry farming. Newcastle disease, avian influenza, and kidney-type spread have become the most common viral diseases that endanger aquaculture. In recent years, new viral diseases such as duck yellow virus disease have become a serious infectious disease that currently endangers breeding ducks. Third, the prevention of viral diseases.
1. Usually strengthen the disinfection and sterilization of the environment.
2. Strengthen feeding management and improve the living environment of livestock.
3. Vaccination at the right time. Injecting corresponding qualified vaccines at the right time and at the right place is currently the main measure to prevent viral diseases.
4. Drug prevention. Usually add some anti-viral, anti-bacterial, and improve the body's immunity to the feed. Tianyu Gankang Polypeptide is mainly used to treat viral diseases of poultry and livestock, which is difficult to control by antibodies. It can quickly improve the body's immunity and improve the disease resistance of animals!
The effect of astragalus extract
Astragalus extract has many chemical components, mainly containing saponins, flavonoids, polysaccharides and amino acids.
This product has the effects of enhancing immunity, enhancing energy, anti-fatigue, anti-mutation, protecting liver, and inhibiting osteoclasts. Traditional Chinese medicine believes that Astragalus has the functions of replenishing qi and promoting yang, consolidating the superficial and antiperspirant, supporting toxins and purging pus, promoting hydration, reducing swelling, and strengthening sore muscles. Modern pharmacological studies have shown that Astragalus has the functions of enhancing the body's immune function, strengthening the heart, lowering blood pressure, lowering blood sugar, diuresis, anti-aging, anti-fatigue, anti-tumor, anti-virus, sedation, analgesia and so on.
Effect on the immune system
Impact on non-specific immune function
Astragalus polysaccharide (APS) can significantly increase the percentage and index of phagocytosis of sheep red blood cells by mice. Astragalus polysaccharides were further separated to obtain three monomeric polysaccharides: 123, and the experiments were carried out separately. The result is that polysaccharide 1 can increase the weight and cell number of the spleen, but inhibit the immune response of spleen cells to sheep red blood cells. 2 is similar to 1 but weaker. Polysaccharide 3 has no effect. Astragaloside can promote the proliferation and differentiation of lymph node B cells and the formation of plasma cell antibodies. Astragalus can promote the formation of specific rosettes of mouse lymphocytes against sheep blood cells. Astragalus polysaccharide significantly enhances the luminescence intensity of macrophages phagocytosis and inhibits the release of PGE2, but further promotes the release of TNF. Cyclooxygenase inhibition of ibuprofen significantly inhibits the release of PGE2 and TNF, and has no significant effect on phagocytosis. Therefore, it can be suggested that the combination of immune activator and cyclooxygenase inhibitor is expected to become a new treatment plan for trauma infection.
Humoral immunity
Astragalus can significantly promote the normal body's antibody production function. Astragalus shows a variety of physiological activities in humoral immunity, enhancing the phagocytic activity of monocytes and macrophages, releasing immunologically active substances to somatic cells and natural killer cells, inducing interferons and interleukins. One of its antiviral principles may be to improve the ability of patients' white blood cells to induce interferon. Normal people take astragalus wholecao extract tablets to significantly increase IgE3. Astragalus can promote the phagocytosis of macrophages, promote the proliferation of B cells and inhibit total complement activity. It has an inducing effect on the production of interleukins, promotes the formation of immune-specific rosettes of mouse lymphocytes on sheep blood cells, and has obvious protective effects on immunosuppressive immunosuppressive disorders. It is a two-way immune regulation Agent. Astragalus polysaccharide is a class of substances with strong immunological activity in Astragalus. It can enhance the phagocytic function of phagocytes. From the weight of spleen and thymus, hemolysin, hemagglutinin and the total number of spleen cells and plaque forming cells, it can be seen that astragalus polysaccharides, Red Qi polysaccharides can completely and partially antagonize the immunosuppressive effects of cyclic phosphate amine or prednisolone.
Effect on cellular immunity Astragalus can promote somatic immune function.
Its effect of enhancing the immune function of human blood lymphocytes may be the result of partially reducing the activity of suppressor T cells. Astragalus polysaccharides can regulate the content and promote the metabolism of phosphatidylinositol, thereby increasing the gene transcription expression of IL-2mRNA and IL-2RmRNA in activated T lymphocytes after trauma. one. The regulation of Astragalus on T cells and the cytokines secreted by Astragalus may be related to its regulation of the production of IgG subclasses.
Effect on natural killer cells
Astragalus can protect target cells against T cell activity, but its degree is not as strong as the promotion of T cell activity. Its enhanced NK cell activity is achieved by inducing lymphocytes to produce type II interferon mediators. Therefore, it is believed that NK cells may be the precursor cells of T cells, and the effect of Astragalus on NK cells is consistent with its activation of T cells.
Effect on induced interferon
Astragalus has obvious stimulating effect on the interferon system, including three aspects: self-induction, promotion of induction and activity. Astragalus itself has a certain anti-tumor effect. Astragalus polysaccharide (5mg/kg) has similar anti-tumor effect to IL-2/LAK, and it has obvious enhancement effect on the anti-tumor effect of IL-2/LAK.
Effect on cellular immunity Astragalus can promote somatic immune function.
Its effect of enhancing the immune function of human blood lymphocytes may be the result of partially reducing the activity of suppressor T cells. Astragalus polysaccharides can regulate the content and promote the metabolism of phosphatidylinositol, thereby increasing the gene transcription expression of IL-2mRNA and IL-2RmRNA in activated T lymphocytes after trauma. one. The regulation of Astragalus on T cells and the cytokines secreted by Astragalus may be related to its regulation of the production of IgG subclasses.
Effect on natural killer cells
Astragalus can protect target cells against T cell activity, but its degree is not as strong as the promotion of T cell activity. Its enhanced NK cell activity is achieved by inducing lymphocytes to produce type II interferon mediators. Therefore, it is believed that NK cells may be the precursor cells of T cells, and the effect of Astragalus on NK cells is consistent with its activation of T cells.
Effect on induced interferon
Astragalus has obvious stimulating effect on the interferon system, including three aspects: self-induction, promotion of induction and activity. Astragalus itself has a certain anti-tumor effect. Astragalus polysaccharide (5mg/kg) has similar anti-tumor effect to IL-2/LAK, and it has obvious enhancement effect on the anti-tumor effect of IL-2/LAK.
Impact on the body's metabolism
Effect on cell metabolism By observing the growth of human fetal kidney cells, human fetal lung diploid cells and mouse kidney cells in a nutrient solution containing astragalus, it is found that Astragalus can enhance the physiological metabolism of cells. After the mice water decoction and normal people took Huangqi dry extract tablets, the plasma CAMp content was significantly increased. Mouse SC astragalus injection can significantly increase the total number of white blood cells and the number of multinucleated white blood cells. Astragalus can also promote the production, development and maturation of various blood cells, and promote the hematopoietic function of bone marrow. For hepatocytes cultured in vitro, Astragalus can promote RNA and protein synthesis, suggesting that it can prolong cell lifespan, enhance cell metabolism and delay aging.
Impact on nucleic acid metabolism
Astragalus polysaccharide (ASP) inhibits the activity of free RN-ase to the extent that kidney <liver <lung <spleen. This result is explained by the relative increase speed of the equilibrium response. The effect of APS is significant in low RI tissues. Astragalus can inhibit the RNA metabolism of human lung diploid cells. Astragalus decoction can significantly promote the DNA synthesis of bone marrow hematopoietic cells and accelerate the process of nucleated cell division. Astragalus saponins can significantly increase the DNA content of regenerating liver, and Astragalus polysaccharides have no obvious effect on DNA metabolism.
Effect on inner cyclic nucleotide
Astragalus decoction can significantly increase the content of internal cyclic nucleotides (cAMP and Cgmp) in mouse plasma and tissues, and its effects on various organs are different; administration increases cAMP and decreases cGMP; the liver is the opposite ; And the increase in the spleen. Further experiments showed that the effect of Astragalus on cAMP was caused by its inhibition of cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE).
Effects on protein and other metabolism
Giving mice astragalus decoction for 10 consecutive days can significantly increase the rate of H-leucine incorporation into serum and liver protein, but has no effect on the protein content, that is, astragalus can promote the renewal of serum and protein in mice, and It is believed that the polysaccharides are likely to be effective ingredients to promote protein renewal. Astragaloside 100g/kg gavage also has a similar effect. Astragalus has a tendency to increase blood sugar levels in insulin-induced hypoglycemia animals, but the increase is small.
The effect on the cardiovascular system
1. Effect on the heart
Astragalus decoction has no obvious effect on the isolated frog heart. The alcohol extract can increase the contraction of the isolated frog or toad heart, and the amplitude is obviously enlarged, but it can inhibit it at high doses. Therefore, astragaloside may achieve cardiotonic effect through NA and K-ATPase. According to reports, Astragalus can increase the content of lactate dehydrogenase and succinate dehydrogenase in human cardiomyocytes in different ways. The above suggests that Astragalus has a calcium antagonistic effect, which can reduce the flow of myocardial CA caused by viral infection, may reduce the secondary CA damage of infected cells, and has an inhibitory effect on the replication of viral RNA in cells, showing its role in viral myocarditis. Application value in clinical treatment. But a single dose of Astragalus has no preventive effect on CVB3 myocarditis. Astragaloside has a positive inotropic effect on the myocardium, similar to cardiac glycosides. Experiments show that the total saponins of astragalus can significantly improve the contractility of the heart in dogs with myocardial infarction, enhance coronary flow, and have a protective effect on heart function. Studies have shown that the effect of astragalus against oxygen free radicals may be one of the mechanisms of heart strengthening. Astragaloside IV injection is an effective inotropic drug other than digitalis.
2. Effects on blood vessels and blood pressure
Astragalus has the effect of expanding blood vessels and expanding coronary arteries. Therefore, it is believed that its antihypertensive effect is the result of direct expansion of peripheral blood vessels, and has no relationship with the heart, and has no relationship with the release of histamine or the effect of adrenergic receptors. It shows that the influence of Astragalus on blood pressure is related to the central neuropeptide, renin-angiotensin-aldosterone system, carnosine releasing enzyme-carnosine system, and hydroxyproline. The antihypertensive component of Astragalus was once considered to be an alkaline substance, but later it was discovered that the roots of Astragalus plants contain aminobutyric acid, and its content is almost parallel to the antihypertensive effect, so it is considered to be an effective component for antihypertensive. In terms of vascular effects, GABA does not completely represent astragalus. Astragalus can promote the migration and proliferation of vascular endothelial cells to varying degrees, which is beneficial to the process of angiogenesis. Astragalus membranaceus saponins II, III, IV and other saponins and formononetin, verbasil isoflavones and other isoflavone compounds in Astragalus membranaceus can significantly improve the deformability of hatching erythrocytes. This may be important for Astragalus membranaceus to improve hemorheological indicators. Mechanism, an important part of the effect of Astragalus on human erythrocyte membrane may be to protect human erythrocyte membrane from the attack of free radicals.
Impact on stress response
1. Anti-fatigue effect
Astragalus polysaccharide 250mg/kg, 500mg/kg intraperitoneal injection, on normal mice and hydrocortisone-induced "Yang deficiency" mice, swimming time at room temperature have a significant effect on swimming time, and increase the weight of the adrenal glands of mice under stress. Astragalus extract can significantly increase the plasma cortisol content, adrenal gland weight, and lipid vacuole content in adrenal cortex cells in rats under swimming stress. Cerebral hypoxia caused by ligation of the carotid arteries on both sides has a significant antagonistic effect, which can significantly prolong the survival time of mice.
2. Resistance to low temperature and high temperature
Astragalus polysaccharide 250mg/kg, 500mg/kg, intraperitoneal injection, can significantly enhance the low temperature tolerance of normal mice, hungry mice and hydrocortisone-treated mice, so that the survival time is significantly improved; but there is no obvious high temperature tolerance. 5.4.3 "Anti-radiation effect Astragalus total flavonoids have a certain protective effect on the immune system damage caused by this kind of radiation. The mechanism of action may be related to the anti-oxidation and free radical scavenging effects of the total flavonoids of astragalus, which can prevent immune cells from lipid peroxidation damage. At the same time, the total flavonoids of astragalus may also have the function of changing the energy metabolism of immune cells and promoting the division of lymphocytes.
Long-term use of anti-aging effect
Astragalus has certain significance for preventing senile arteriosclerosis and improving senile lung function. Human embryonic lung diploid fibroblasts cultured in vitro survived to 52 generations, while cultured cells containing 0.2% astragalus extract survived to 77 generations. The changes of organelles during the aging process of the drug group and the control group were compared with those of the control group. Basically the same, but the degree of change is light, and the rate of change is relatively slow, especially the Golgi complex of the cells in the drug group is particularly developed. Although the cells are senescent, they are not very senescent. Studies have proved that Astragalus has a good effect on prolonging life. As an anti-aging and prolonging drug, it is worthy of great attention and development.
Effects on the urinary system
Intravenous injection of astragalus injection can significantly increase the serum albumin of the rat minimally changed nephropathy model, significantly reduce the serum cholesterol, and increase the blood flow of the glomerular capillary filaments, and also significantly reduce the scrotal edema and ascites. The diet and mental state of the animals in the administration group are also better than those of the control group; Astragalus can significantly reduce the amount of protein in the urine; pathological observations have also proved that the astragalus group has reduced lesions, and this inhibitory effect on nephritis may be related to the enhanced metabolism of Astragalus. It is related to improving the nutritional status of the whole body. Astragalus can alleviate kidney disease in spontaneous lupus mice through immunomodulatory effects.
Hepatoprotective effect
Astragalus can protect the liver and prevent the reduction of liver glycogen. Two kinds of astragaloside ASI and SK can resist liver damage caused by D-galactosamine and acetaminophen. Astragaloside is an effective component of Astragalus against hepatotoxic damage. Its mechanism is not only anti-biooxidation, but also related to metabolic regulation. Another study believes that Astragalus has a certain effect on preventing liver fibrosis.
Effects on the central nervous system
Subcutaneous injection of astragalus to mice can maintain a sedative effect for several hours. Mice drinking 30% astragalus decoction for 15 days can strengthen the learning and memory of mice. Experiments show that astragalus is beneficial to the storage of information in the brain of mice.
Effect on smooth muscle
5% and 10% astragalus decoction can significantly increase the intestinal tension of rabbits in vivo, slow down the peristalsis, and increase the amplitude; it has inhibitory effect on the isolated rabbit intestines and uterus. Astragaloside can reduce the tension of the isolated ileum of guinea pigs.
Hormone-like effects
Astragalactone and astragalus sterol in astragalus extract have no significant effect on the weight of rats, mice, levator ani muscle or kidney, indicating that there is no anabolic hormone or androgen-like effect.
Antibacterial, antiviral and antitumor effects
Astragalus polysaccharides have obvious antagonistic effects on tuberculosis infection; other ingredients such as amino acids, alkaloids, flavonoids, etc. have been found to have significant anti-follicular stomatitis virus effects. Animal and transmutation cell experiments show that Astragalus injection has a certain blocking effect on the infection process of epidemic hemorrhagic fever and virus (EHFV) in suckling mice. Astragalus against Shigella Shigella, Bacillus anthracis, Alpha-Activated Streptococcus, Streptococcus sanguis, Diphtheria, Pseudodiphtheria, Pneumococcus, Staphylococcus aureus, Staphylococcus citrus, Staphylococcus albicans, Bacillus subtilis, etc. Has antibacterial effect.
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