Topical Solution (imidacloprid + moxidectin Drop)
Pet External Use Drug
Name: Imidacloprid and Moxidectin Spot-on Solutions (for Cats)
Compostion: Imidacloprid, Moxidectin
Character: This product is yellow to brown liquid.
Pharmacological effects antiparasite drug
Pharmacodynamics: Imidacloprid is a new generation of chlorinated nicotine insecticide, which affects the postsynaptic nicotinic acetylcholine in the central nervous system of insects.
Alkali receptors have high affinity and inhibit acetylcholine activity, leading to paralysis and death of the parasite. It is effective against adult fleas and juvenile fleas in all stages, and also has a killing effect on juvenile fleas in the environment. The mechanism of action of moxidectin is similar to that of avermectin and ivermectin. It has a good repellent effect on internal and external parasites, especially nematodes and arthropods. Its mechanism of anthelmintic action is to promote the neurotransmitter γ-amino acid. The release of butyrate (GABA) increases its binding force to postsynaptic receptors and opens chloride channels. Moxidectin also has selectivity and high affinity for glutamate-mediated chloride channels, thereby interfering with neuromuscular signal transmission, causing relaxation and paralysis of the worm, leading to death of the worm. Inhibitory interneurons and excitatory motor neurons in nematodes are its sites of action, while in arthropods the site of action is the neuromuscular junction. The two are used together to have a synergistic effect.
Pharmacokinetics: After the first dose, imidacloprid is rapidly distributed to the cat's body surface on the same day and remains on the cat's body surface between doses. 1 to 2 days after administration, the plasma concentration of moxidectin reaches its highest level in cats, and is distributed throughout the body and slowly metabolized and excreted within a month.
Indications For the prevention and treatment of internal and external parasitic infections in dogs. Prevention and treatment of flea infestations (Ctenophora felis), treatment of tick infestations (Trichopterus canis), treatment of ear mite infestations (T. auris), canine sarcoptic mange (Scabies) and demodicosis (Demodex canis) , treatment of Angiostrongylus and gastrointestinal nematode infections (adult worms, immature adults and L4 stage larvae of Toxocara canis, Ancylostoma canis and Ancylostoma canis; adults of Toxocara leonata and Trichocystis lepiensis), prevention of heart disease Filariasis (L3 and L4 stage larvae of Dirofilaria immitis), treatment of circulating microfilariae (Dirofilaria immitis). It can also assist in the treatment of allergic dermatitis caused by fleas.
Usage & Dosage: Based on this product. External use: One dose, 0.1ml per 1kg body weight for dogs. During prevention or treatment, administer once a month. To prevent dogs from licking, this product can be dropped on the skin from between the shoulder blades to the buttocks on the dog's back, and can be added in 3 to 4 places. Please refer to the instruction manual for details of dosing regimen.
| Cat B.W.(kg) |
Applicable product type |
Volume(ml) |
Imidacloprid
(mg/kg B.W.) |
Moxidectin(mg/kg B.W.) |
| ≤4kg |
For little dogs |
0.4 ml |
Not less than 10 |
Not less than 2.5 |
| >4~10kg |
For middle dogs |
1.0 ml |
10~25 |
2.5~6.25 |
| >10~25kg |
For large dogs |
2.5 ml |
10~25 |
2.5~6.25 |
| >25~40kg |
For extra large dogs |
4.0 ml |
10~16 |
2.5~4.0 |
| >40 kg |
Use a combination of products with appropriate specifications |
Prevent and treat flea infestations: One dose can prevent re-infestations for 4 weeks. Flea pupae already present in the environment can hatch in 6 weeks or longer, depending on the local climate. In order to cut off the life history of fleas in the natural environment, the use of this product should be combined with environmental treatment.
Treatment of lice infestation: Single dose, veterinary examination and evaluation 30 days after administration will determine whether a second dose is required.
Treatment of ear mite infection: single administration. Loose ear debris in the external auditory canal should be removed before administration. A second dose will be determined after veterinary examination and evaluation 30 days after administration.
Treatment of scabies mite infection: Administer once every 4 weeks, 2 times in a row.
Treatment of Demodex infection: Administration once every 4 weeks for 2 to 4 months can effectively prevent and treat the occurrence of demodicosis in dogs and significantly improve clinical symptoms; longer and more frequent treatments may be required for severe infections. This product can be used once a week or longer depending on the veterinary examination. In all cases, treatment should be continued until the skin flakes are normal for at least 2 consecutive months. Dogs that do not improve or the number of mites does not decrease after two months of treatment should stop using it and be given other drug treatments under the guidance of a veterinarian. Because demodicosis is a multifactorial disease, the underlying disease should be treated if possible.
Treatment of Angiostrongylus infection: single administration, veterinary examination and evaluation 30 days after administration will determine whether a second administration is required. Routine monthly dosing in endemic areas can prevent Angiostrongylus larvae migrans and overt infection with Angiostrongylus.
Prevention of heartworm disease: For dogs living in or passing through areas where heartworm is endemic, this product can be used once a month throughout the year or one month before the mosquito (intermediate host, carrying and transmitting heartworm larvae) activity season. , until one month after the mosquito campaign ends. To determine the treatment plan, it is recommended that the drug be administered on the same day each month. When substituting this product for another heartworm preventive product, the first use should be within one month of the last dose of the other product.
Treatment of circulating microfilariae: Administer once a month, twice in a row.
Adverse reactions:
1. This product can cause temporary itching, and animals occasionally (<1/10000<incidence rate<10/10000) may experience hair adhesion, erythema or vomiting. These symptoms will disappear without treatment. Animals using this product may occasionally cause local allergic reactions.
2. After administration, if the animal licks the administration site, very few animals (<1/10000) may develop transient neurological symptoms, such as excitement, tremor, ophthalmological symptoms (pupil dilation, decreased pupillary reflex, and nystagmus). ), breathing abnormalities, salivation and vomiting, etc.; very rarely, transient behavioral changes may occur, such as reluctance to exercise, excitement, and loss of appetite.
3. Field trials have shown that heartworm-positive dogs with microfilariaemia are at risk for severe respiratory symptoms (coughing, shortness of breath, and difficulty breathing) and may require immediate veterinary treatment. Adverse reactions such as gastrointestinal symptoms (vomiting, diarrhea, loss of appetite) and lethargy are also common in these dogs after using this product.
Note:
1. Not suitable for dogs under 7 weeks old. It is prohibited to use on cats allergic to this product and its accessories. This product has not been evaluated for safety in pregnant or lactating dogs. Veterinary advice must be followed before use.
2. Dogs under 1kg must follow veterinary advice when using this product.
3. For cats who live in or have been to areas where heartworm is endemic, it is recommended that dogs older than 6 months be examined for heartworm infection before using this product. If infection is confirmed, it should be treated according to current scientific methods. Serious adverse events, including death, may occur after use of this product in cats infected with adult heartworm worms.
4. Although this product may be safe when used in dogs infected with adult heartworm worms in overdose trials, this product has no therapeutic effect on adult heartworm worms. Therefore, it is recommended that dogs aged 6 months and above living in areas where heartworm is endemic should be checked for adult heartworm infection before using this product. It is up to your veterinarian to decide whether adult insecticides are needed. The safety of this product when used on the same day as adult insecticides has not been evaluated.
5. This product contains moxidectin (macrolide), so when using this product on Collies, Old English Sheepdogs and related breeds, special attention must be paid to preventing these dogs from licking this product orally.
6. Sick dogs and dogs with weak constitutions must follow veterinary advice when using it.
7. Do not use this product on cats.
8. When using this product, do not let the medicine in the tube come into contact with the eyes and mouth of the animal being administered or other animals. Prevent animals that have used the medicine from licking each other's fur. Do not touch or trim hair before the medicine is dry.
9. During the administration period, the dog's occasional contact with water once or twice will not significantly affect the efficacy of the drug. However, frequent bathing with shampoo or soaking in water may affect the efficacy of the medicine.10. Do not store above 30ºC and do not use beyond the expiry date.
10. Keep this product out of reach of children.
11. Do not store above 30ºC and do not use beyond the expiry date.
12. People who are allergic to this product should not take this medicine.
13. When administering the drug, users should avoid contact with the skin, eyes and mouth, and do not eat, drink or smoke. After administration, the user should wash their hands. If it accidentally splashes on the skin, wash it immediately with soap and water; if it accidentally splashes on the eyes, rinse immediately with water. If symptoms do not improve, please seek medical advice with the instructions.
14. Currently, there is no specific rescue drug for this product; if swallowed by mistake, oral activated charcoal can help detoxify.
15. The solvent in this product may contaminate materials such as leather, fabric, plastic, and painted surfaces. Prevent these materials from contacting the administration site before it dries.
16. Do not let this product enter surface water.
17. Unused drugs and packaging materials should be disposed of harmlessly in accordance with local requirements.
Spec.(1)0.4ml∶40mg+10mg (2)1.0ml∶100mg+25mg
(3)2.5ml: 250mg+62.5mg (4)4.0ml: 400mg+100mg
Packing: 3 tube/box
Shelf Life: 36 Months
Shandong Ginye Biotech Co., Ltd. is a integrated company whose main business is animal pharmaceutical / feed additive / pet products research development, production and trading. Our company cooperate with many famous animal health products research institution such as Shandong Agricultural Academy, China Veterinary Herb Medicine Industry Research Institute, Shandong Herb Medicine University, Shandong Agricultural University etc. to research and sales the latest research results / animal use finished products.
Ginye enterprise vision is concentrate on animal health, promote human-animal-environment harmonious development.
Now we have 2 modern GMP factories(10 production lines ) to produce more than one hundred products. Our products include:
powder / oral solution / liquid injection / premix / tablet / injectable powder / granula / herbal extract , annual production value more than 1 billion RMB .
We always insist the concept of market-globalization, actively promote animal health products field grow fastly , so always work hard to exploit international market, we have established extensive business contacts with more than 30 overseas countries and regions, such as southeast asia , south aisa , middle asia , middle east , east europe, and products register work are going on in tens of countries.
GinYe expect to cooperate with all kinds of good friends and partners in animal health care industry, harvest hope / create glory in golden field.
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